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Literature summary for 2.2.1.6 extracted from

  • Barak, Z.; Chipman, D.M.; Gollop, N.
    Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria (1987), J. Bacteriol., 169, 3750-3756.
    View publication on PubMedView publication on EuropePMC
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1
-
 pyruvate pH 7.6, isoenzyme AHAS I Escherichia coli
7
-
 pyruvate pH 7.6, isoenzyme AHAS III Escherichia coli
10.6
-
 pyruvate pH 7.6, isoenzyme AHAS II Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate Salmonella enterica subsp. enterica serovar Typhimurium isoenzyme AHAS I enables a bacterium to cope with poor carbon sources, which lead to low endogenous pyruvate concentrations ?
-
 ?
pyruvate Escherichia coli isoenzyme AHAS I enables a bacterium to cope with poor carbon sources, which lead to low endogenous pyruvate concentrations ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 3 isoenzymes: I, II, and III
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
 3 isoenzymes: I, II, and III
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-acetolactate + CO2
-
 ?
pyruvate
-
 Escherichia coli 2-acetolactate + CO2
-
 ?
pyruvate isoenzyme AHAS I enables a bacterium to cope with poor carbon sources, which lead to low endogenous pyruvate concentrations Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
pyruvate isoenzyme AHAS I enables a bacterium to cope with poor carbon sources, which lead to low endogenous pyruvate concentrations Escherichia coli ?
-
 ?
pyruvate + 2-oxobutanoate isoenzyme I shows no product preference, isoenzymes II and III form acetohydroxybutanoate at 180fold and 60fold faster rates, respectively than acetolactate Salmonella enterica subsp. enterica serovar Typhimurium acetohydroxybutanoate
-
 ?
pyruvate + 2-oxobutanoate isoenzyme I shows no product preference, isoenzymes II and III form acetohydroxybutanoate at 180fold and 60fold faster rates, respectively than acetolactate Escherichia coli acetohydroxybutanoate
-
 ?