Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.2.1.2 extracted from

  • Perl, A.; Qian, Y.; Chohan, K.R.; Shirley, C.R.; Amidon, W.; Banerjee, S.; Middleton, F.A.; Conkrite, K.L.; Barcza, M.; Gonchoroff, N.; Suarez, S.S.; Banki, K.
    Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa (2006), Proc. Natl. Acad. Sci. USA, 103, 14813-14818.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.2.1.2

Application

Application Comment Organism
medicine male mice lacking transaldolase are sterile because of defective forward motility of spermatozoa. Transaldolase -/- spermatozoa show loss of transmembrane potential and mitochondrial membrane integrity. Lack of enzyme influencies structure and function of mitochondria without compromising the nucleus and DNA integrity. Stimulation of de novo glutathione synthesis by oral N-acetyl-cysteine normalizes the low fertility rates of transaldolase +/- males without affecting the sterility of transaldolase -/- mice Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
partial DNA and amino acid sequence determination and analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information TAL gene inactivation by homologous recombination, partial inactivation leads to partial male infertility, complete knockout leads to complete male infertility, TAL deficiency influences the structure and function of mitochondria without compromising the nucleus and DNA integrity and leads to accumulation of sedoheptulose 7-phosphate and depletion of pyridine nucleotides in TAL-deficient tissues, genotypes and phenotypes, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus essential role of transaldolase in sperm-cell mitochondrial function ?
-
 ?
additional information Mus musculus the enzyme is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male, homo- or heterozygously lacking transaldolase
-
Mus musculus Q2TUQ1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
germ cell
-
 Mus musculus
-
spermatozoon
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information essential role of transaldolase in sperm-cell mitochondrial function Mus musculus ?
-
 ?
additional information the enzyme is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
TAL
-
 Mus musculus