Literature summary for 2.2.1.1 extracted from

Domain, F.; Bina, X.; Levy, S.
Transketolase A, an enzyme in central metabolism, derepresses the marRAB multiple antibiotic resistance operon of Escherichia coli by interaction with MarR (2011), Mol. Microbiol., 80, 853-853.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Expression

Organism	Comment	Expression
Escherichia coli	hydrogen peroxide induces enzyme expression at 1 h treatment, while an increase in expression of the marRAB operon occurrs only after 3 h exposure and is dependent on the presence of the enzmye gene	up

General Information

General Information	Comment	Organism
physiological function	Overexpression or deletion of the enzyme gene interferes with MarR repression of the marRAB operon. Deletion of enzyme gene increases antibiotic and oxidative stress susceptibilities, while its overexpression decreases them	Escherichia coli

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Release 2023.1 (January 2023)