Application | Comment | Organism |
---|---|---|
medicine | is crucial for optimal brain function. Abnormal transketolase expression and/or activity are implicated in a number of diseases where thiamin availability is low, including Wernicke-Korsakoffs Syndrome and alcoholism | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | activity of transketolase is significantly reduced in brains of alcoholic patients with Wernicke-Korsakoffs Syndrome. Reduced transketolase protein expression levels in autopsied prefrontal white and grey matter and cerebellar vermis samples from neurologically uncomplicated alcoholics and alcoholics with liver cirrhosis | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
2 * 70000 | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-xylulose 5-phosphate + D-ribose 5-phosphate | - |
Homo sapiens | sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | - |
r |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 70000 | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thiamine diphosphate | - |
Homo sapiens |