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Literature summary for 2.2.1.1 extracted from

  • Alexander-Kaufman, K.; Harper, C.
    Transketolase: Observations in alcohol-related brain damage research (2009), Int. J. Biochem. Cell Biol., 41, 717-720.
    View publication on PubMed

Application

Application Comment Organism
medicine is crucial for optimal brain function. Abnormal transketolase expression and/or activity are implicated in a number of diseases where thiamin availability is low, including Wernicke-Korsakoff’s Syndrome and alcoholism Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information activity of transketolase is significantly reduced in brains of alcoholic patients with Wernicke-Korsakoff’s Syndrome. Reduced transketolase protein expression levels in autopsied prefrontal white and grey matter and cerebellar vermis samples from neurologically uncomplicated alcoholics and alcoholics with liver cirrhosis Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
2 * 70000 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-xylulose 5-phosphate + D-ribose 5-phosphate
-
Homo sapiens sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
-
r

Subunits

Subunits Comment Organism
homodimer 2 * 70000 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
Homo sapiens