Literature summary for 2.2.1.1 extracted from

Zerilli, M.; Amato, M.C.; Martorana, A.; Cabibi, D.; Coy, J.F.; Cappello, F.; Pompei, G.; Russo, A.; Giordano, C.; Rodolico, V.
Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases (2008), Cancer, 113, 936-944.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	increased levels of TKTL1 transcript in tumors compared with their corresponding normal tissues. Positive correlation between TKTL1 protein expression in primary tumors and the number of metastatic lymph-nodes as well as the diameter of the largest metastatic area in lymph-nodes. High levels of TKTL1 transcript are a relevant phenomenon in small PTCs	Homo sapiens

Application

Application	Comment	Organism
medicine	TKTL1 overexpression in papillary thyroid carcinoma bigger than 1.5 cm may be considered a factor that facilitates tumor growth and progression. Significant association between TKTL1 protein expression and the presence of multifocality, bilaterality, extrathyroidal extension, vascular invasion, sclerosis, and lymph-node metastases	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	papillary thyroid carcinoma with or without lymph-node metastases	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
TKTL1	-	Homo sapiens
transketolase-like 1	-	Homo sapiens

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Release 2023.1 (January 2023)