Literature summary for 2.2.1.1 extracted from

Hu, L.H.; Yang, J.H.; Zhang, D.T.; Zhang, S.; Wang, L.; Cai, P.C.; Zheng, J.F.; Huang, J.S.
The TKTL1 gene influences total transketolase activity and cell proliferation in human colon cancer LoVo cells (2007), Anticancer Drugs, 18, 427-433.

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Application

Application	Comment	Organism
medicine	the transketolase-like-1 gene plays an important role in total transketolase activity and in cell proliferation of human colon cancer. Transketolase-like-1 may serve as a target for novel anticancer therapies	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
RNAi	transketolase-like-1 gene is significantly downregulated in human colon cancer cell line cells transfected with small interfering RNA transketolase-like-1 constructs compared with cells transfected with control vector and cells without transfection. Anti-transketolase-like-1 small interfering RNA construct significantly decreases the level of transketolase in the transfected human colon cancer cell line cells, arrests them in G0/G1 phase and substantially inhibits cell proliferation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colonic cancer cell	-	Homo sapiens	-
LoVo cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
TKTL1	-	Homo sapiens
transketolase-like-1	-	Homo sapiens

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Release 2023.1 (January 2023)