Literature summary for 2.1.4.2 extracted from

Walker, J.B.
L-Arginine:inosamine-P amindinotransferase (s) (1975), Methods Enzymol., 43, 451-458.

Inhibitors

Inhibitors	Comment	Organism
cystamine	-	Streptomyces bikiniensis
cystamine	-	Streptomyces hygroscopicus
cystine	-	Streptomyces bikiniensis
cystine	-	Streptomyces hygroscopicus
formamidine disulfidedihydrochloride	-	Streptomyces bikiniensis
formamidine disulfidedihydrochloride	-	Streptomyces hygroscopicus
ornithine	product inhibition, most potent competitive inhibitor	Streptomyces bikiniensis
ornithine	product inhibition, most potent competitive inhibitor	Streptomyces hygroscopicus
p-chloromercuribenzoate	-	Streptomyces bikiniensis
p-chloromercuribenzoate	-	Streptomyces hygroscopicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	Streptomyces griseocarneus	-	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	Streptomyces galbus	-	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	Streptomyces humidus	-	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	Streptomyces ornatus	-	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	Streptomyces bikiniensis	biosynthesis of streptomycin	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	Streptomyces hygroscopicus	biosynthesis of streptomycin	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Streptomyces bikiniensis	-	ATCC 11062	-
Streptomyces galbus	-	ATCC 14077	-
Streptomyces griseocarneus	-	ATCC 12628	-
Streptomyces humidus	-	ATCC 12760	-
Streptomyces hygroscopicus	-	forma glebosus, ATCC 14607	-
Streptomyces ornatus	-	ATCC 23265	-

Purification (Commentary)

Purification (Comment)	Organism
-	Streptomyces bikiniensis
-	Streptomyces hygroscopicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
mycelium	-	Streptomyces bikiniensis	-
mycelium	-	Streptomyces hygroscopicus	-
mycelium	-	Streptomyces griseocarneus	-
mycelium	-	Streptomyces galbus	-
mycelium	-	Streptomyces humidus	-
mycelium	-	Streptomyces ornatus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.17	-	-	Streptomyces bikiniensis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
arginine + 1,4-diaminobutylphosphonic acid	-	Streptomyces bikiniensis	ornithine + ?	-	?
arginine + 2-amino-2-deoxy-neoinositol 5-phosphate	-	Streptomyces bikiniensis	ornithine + ?	-	?
arginine + 2-amino-2-deoxy-neoinositol 5-phosphate	-	Streptomyces hygroscopicus	ornithine + ?	-	?
arginine + 2-deoxystreptamine 6-phosphate	-	Streptomyces bikiniensis	N-amidino-2-deoxystreptamine 6-phosphate + ornithine	-	?
arginine + 2-deoxystreptamine 6-phosphate	-	Streptomyces hygroscopicus	N-amidino-2-deoxystreptamine 6-phosphate + ornithine	-	?
arginine + 2-deoxystreptidine	-	Streptomyces bikiniensis	ornithine + ?	-	?
arginine + 2-deoxystreptidine	-	Streptomyces hygroscopicus	ornithine + ?	-	?
arginine + scyllo-inosamine 4-phosphate	-	Streptomyces bikiniensis	ornithine + N-amidino-scyllo-inosamine-4-phosphate	-	?
arginine + scyllo-inosamine 4-phosphate	-	Streptomyces hygroscopicus	ornithine + N-amidino-scyllo-inosamine-4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	-	Streptomyces griseocarneus	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	-	Streptomyces galbus	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	-	Streptomyces humidus	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	-	Streptomyces ornatus	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	biosynthesis of streptomycin	Streptomyces bikiniensis	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate	biosynthesis of streptomycin	Streptomyces hygroscopicus	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate	-	Streptomyces bikiniensis	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate	-	Streptomyces hygroscopicus	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate	-	Streptomyces griseocarneus	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate	-	Streptomyces galbus	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate	-	Streptomyces humidus	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate	-	Streptomyces ornatus	L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate	-	?
L-canavanine + L-ornithine	-	Streptomyces bikiniensis	L-canaline + L-arginine	-	r
L-canavanine + L-ornithine	-	Streptomyces hygroscopicus	L-canaline + L-arginine	-	r
additional information	inosamine derivatives must be phosphorylated to serve as substrates, phosphates must be esterified with the hydroxyl group para to the amino group to be transamidinated	Streptomyces bikiniensis	?	-	?
streptidine phosphate + glycylglycine	-	Streptomyces bikiniensis	?	-	?
streptidine phosphate + glycylglycine	-	Streptomyces griseocarneus	?	-	?