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Literature summary for 2.1.3.3 extracted from
- Characterization of the human ornithine transcarbamylase 3 untranslated regulatory region (2012), DNA Cell Biol., 31, 427-433.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| three different splicing isoforms, OTC-t1, OTC-t2, and OTC-t3, all three isoforms use a canonical AAUAAA hexamer that is predicted to fold into a hairpin secondary structure which might be exposed to the cleavage and polyadenylation specificity factor. In addition, the OTC-t1 and OTC-t2 transcripts display heterogeneity at the cleavage sites in a tissue-dependent manner. Secondary structure of the OTC mRNA polyA signals, overview | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P00480 | mRNA isoforms OTC-t1, OTC-t2, and OTC-t3 are transcribed from the OTC gene | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | OTC-t3 | Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| additional information | two major transcripts, OTC-t1 and OTC-t2, are more highly expressed than any of the other isoforms in all the tissues analyzed | Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| small intestine | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | OTC-t1 and OTC-t2 transcripts display heterogeneity at the cleavage sites in a tissue-dependent manner | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ornithine transcarbamylase | - |
Homo sapiens |
| ornithine transcarbamylase 3 | - |
Homo sapiens |
| OTC | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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