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Literature summary for 2.1.3.3 extracted from

  • Marshall, M.; Cohen, P.P.
    Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. II. Multiple binding sites for carbamyl-P and L-norvaline, correlation with steady state kinetics (1972), J. Biol. Chem., 247, 1654-1668.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Carbamoyl phosphate
-
Enterococcus faecalis
DL-2-Amino-5-hydroxypentanoic acid
-
Bos taurus
DL-2-Amino-5-hydroxypentanoic acid
-
Enterococcus faecalis
L-2,4-diaminobutyric acid
-
Bos taurus
L-2,4-diaminobutyric acid
-
Enterococcus faecalis
L-2-aminobutyrate L-isomer Bos taurus
L-2-aminobutyrate L-isomer Enterococcus faecalis
L-alanine
-
Bos taurus
L-alanine
-
Enterococcus faecalis
L-leucine
-
Bos taurus
L-leucine
-
Enterococcus faecalis
L-norleucine
-
Bos taurus
L-norleucine
-
Enterococcus faecalis
L-norvaline
-
Bos taurus
L-norvaline
-
Enterococcus faecalis
phosphate
-
Enterococcus faecalis

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Enterococcus faecalis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-ornithine highly specific for L-ornithine at pH 8.0 Bos taurus phosphate + L-citrulline
-
?
carbamoyl phosphate + L-ornithine highly specific for L-ornithine at pH 8.0 Enterococcus faecalis phosphate + L-citrulline
-
?
carbamoyl phosphate + lysine at alkaline pH Bos taurus phosphate + homocitrulline
-
?
carbamoyl phosphate + lysine at alkaline pH Enterococcus faecalis phosphate + homocitrulline
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
90
-
L-citrulline
-
Enterococcus faecalis
187
-
ornithine
-
Bos taurus
3400
-
ornithine
-
Enterococcus faecalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
ornithine synthesis Enterococcus faecalis
8.4
-
-
Enterococcus faecalis
8.5
-
-
Bos taurus
8.5
-
citrulline synthesis Enterococcus faecalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki for norvaline varies with pH, carbamoyl phosphate or phosphate concentration Enterococcus faecalis
0.012
-
Carbamoyl phosphate at 25°C and pH 8.4 Enterococcus faecalis
8
-
phosphate at 25°C and pH 7.1 Enterococcus faecalis