Crystallization (Comment) | Organism |
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crystals are grown at 295 K by the sitting-drop method from reservoirs containing 2.0 M ammonium sulfate and 5% 2-propanol. The catalytic trimer is crystallized in space group R32, with unit-cell parameters a = b = 265.3, c = 195.5 A and two trimers in the asymmetric unit. Its structure is determined using molecular replacement and Patterson methods | Methanocaldococcus jannaschii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbamoyl phosphate + L-aspartate | Methanocaldococcus jannaschii | the enzyme catalyzes the first step in the pyrimidine biosynthetic pathway | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | Methanocaldococcus jannaschii DSM 2661 | the enzyme catalyzes the first step in the pyrimidine biosynthetic pathway | phosphate + N-carbamoyl-L-aspartate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanocaldococcus jannaschii | Q58976 | - |
- |
Methanocaldococcus jannaschii DSM 2661 | Q58976 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbamoyl phosphate + L-aspartate | - |
Methanocaldococcus jannaschii | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | the enzyme catalyzes the first step in the pyrimidine biosynthetic pathway | Methanocaldococcus jannaschii | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Methanocaldococcus jannaschii DSM 2661 | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | the enzyme catalyzes the first step in the pyrimidine biosynthetic pathway | Methanocaldococcus jannaschii DSM 2661 | phosphate + N-carbamoyl-L-aspartate | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | - |
Methanocaldococcus jannaschii |
Synonyms | Comment | Organism |
---|---|---|
aspartate transcarbamoylase | - |
Methanocaldococcus jannaschii |
ATCase | - |
Methanocaldococcus jannaschii |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme catalyzes the first step in the pyrimidine biosynthetic pathway | Methanocaldococcus jannaschii |