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Literature summary for 2.1.3.2 extracted from

  • Coudray, L.; Pennebaker, A.F.; Montchamp, J.L.
    Synthesis and in vitro evaluation of aspartate transcarbamoylase inhibitors (2009), Bioorg. Med. Chem., 17, 7680-7689.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-(4-hydroxy-2,4-dioxo-4lamdba5-[1,4]azaphosphinan-1-yl)-succinic acid competitive Escherichia coli
N-(2-hydroxy-acetyl)-L-aspartic acid-phosphate competitive Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-aspartate
-
Escherichia coli phosphate + N-carbamoyl-L-aspartate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00021
-
N-(2-hydroxy-acetyl)-L-aspartic acid-phosphate catalytic subunit of aspartate transcarbamoylase Escherichia coli
0.001
-
2-(4-hydroxy-2,4-dioxo-4lamdba5-[1,4]azaphosphinan-1-yl)-succinic acid catalytic subunit of aspartate transcarbamoylase Escherichia coli