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Literature summary for 2.1.3.2 extracted from

  • Burns, B.P.; Mendz, G.L.; Hazell, S.L.
    In situ properties of Helicobacter pylori aspartate carbamoyltransferase (1997), Arch. Biochem. Biophys., 347, 119-125.
    View publication on PubMed
Search for more literature for 2.1.3.2

Inhibitors

Inhibitors Comment Organism Structure
acetyl phosphate 3 mM, 50% inhibition Helicobacter pylori
CDP 10 mM, 61% inhibition Helicobacter pylori
CTP 10 mM, 79% inhibition Helicobacter pylori
GTP
-
 Helicobacter pylori
Maleate 15 mM, 50% inhibition Helicobacter pylori
N-(Phosphonoacetyl)-L-aspartate 0.0001 mM, 50% inhibition Helicobacter pylori
Phosphonoacetic acid 1 mM, 50% inhibition Helicobacter pylori
succinate 10 mM, 50% inhibition Helicobacter pylori

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.61
-
 Carbamoyl phosphate in cell extracts Helicobacter pylori
11.6
-
 L-aspartate in cell extracts Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
carbamoylphosphate + L-aspartate Helicobacter pylori
-
 phosphate + N-carbamoyl-L-aspartate
-
 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-aspartate
-
 Helicobacter pylori phosphate + N-carbamoyl-L-aspartate
-
 ?
carbamoylphosphate + L-aspartate
-
 Helicobacter pylori phosphate + N-carbamoyl-L-aspartate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
-
 Helicobacter pylori

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 sharp decline in activity below and above Helicobacter pylori