Activating Compound | Comment | Organism | Structure |
---|---|---|---|
adenosine | very weak activation | Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
X-ray structure at 5.5 A resolution | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-ThioUMP | - |
Escherichia coli | |
CTP | 800-1000 mM urea lower or eliminate CTP inhibition | Escherichia coli | |
CTP | - |
Halobacterium salinarum | |
CTP | - |
Pseudomonas aeruginosa | |
CTP | - |
Pseudomonas fluorescens | |
CTP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
cytidine | - |
Escherichia coli | |
diphosphate | - |
Enterococcus faecalis | |
diphosphate | - |
Escherichia coli | |
diphosphate | - |
Pseudomonas fluorescens | |
GTP | - |
Escherichia coli | |
GTP | - |
Pseudomonas aeruginosa | |
GTP | - |
Vigna radiata var. radiata | |
Inosine | - |
Escherichia coli | |
ITP | weak inhibition | Escherichia coli | |
N-(Phosphonoacetyl)-L-aspartate | - |
Bacillus subtilis | |
N-(Phosphonoacetyl)-L-aspartate | - |
Escherichia coli | |
N-(Phosphonoacetyl)-L-aspartate | - |
Mus musculus | |
N-(Phosphonoacetyl)-L-aspartate | - |
Vigna radiata var. radiata | |
N-methyl phosphonoacetamide | - |
Escherichia coli | |
nucleotides | - |
Citrobacter freundii | |
nucleotides | - |
Escherichia coli | |
nucleotides | - |
Pseudomonas aeruginosa | |
nucleotides | - |
Pseudomonas fluorescens | |
phosphonoacetamide | - |
Escherichia coli | |
UTP | weak inhibition | Escherichia coli | |
UTP | - |
Pseudomonas aeruginosa | |
UTP | - |
Pseudomonas fluorescens | |
UTP | - |
Saccharomyces cerevisiae | |
UTP | - |
Vigna radiata var. radiata |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | regulatory subunit contains 6 Zn2+ per 300000 Da protein, Zn2+ may be replaced by Hg2+ or Cd2+ | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
93000 | - |
- |
Vigna radiata var. radiata |
93000 | - |
250000 Da and 93000 Da isoforms | Citrobacter freundii |
100000 | - |
100000 Da and 300000 Da isofomrms | Pseudomonas vulgaris |
120000 | 140000 | - |
Enterococcus faecalis |
250000 | - |
250000 Da and 93000 Da isoforms | Citrobacter freundii |
300000 | - |
100000 Da and 300000 Da isoforms | Salmonella enterica subsp. enterica serovar Typhimurium |
300000 | - |
100000 Da and 300000 Da isoforms | Pseudomonas aeruginosa |
300000 | - |
100000 Da and 300000 Da isoforms | Serratia marcescens |
300000 | - |
100000 Da and 300000 Da isoforms | Azotobacter vinelandii |
300000 | - |
100000 Da and 300000 Da isoforms | Pseudomonas vulgaris |
310000 | - |
sedimentation equilibrium | Escherichia coli |
360000 | - |
- |
Pseudomonas fluorescens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbamoylphosphate + L-aspartate | Salmonella enterica subsp. enterica serovar Typhimurium | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Vigna radiata var. radiata | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Bacillus subtilis | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Mus musculus | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Rattus norvegicus | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Saccharomyces cerevisiae | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Triticum aestivum | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Oryctolagus cuniculus | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Neurospora crassa | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Pseudomonas fluorescens | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Klebsiella aerogenes | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Pseudomonas aeruginosa | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Halobacterium salinarum | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Serratia marcescens | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Enterococcus faecalis | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Azotobacter vinelandii | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Lactuca sativa | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Citrobacter freundii | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Pseudomonas vulgaris | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | Escherichia coli | catalyzes the formation of carbamoyl-L-aspartate, the first compound unique to the biosynthetic pathway for pyrimidine nucleotides | phosphate + N-carbamoyl-L-aspartate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Azotobacter vinelandii | - |
- |
- |
Bacillus subtilis | - |
- |
- |
Citrobacter freundii | - |
- |
- |
Enterococcus faecalis | - |
- |
- |
Escherichia coli | - |
- |
- |
Halobacterium salinarum | - |
- |
- |
Klebsiella aerogenes | - |
- |
- |
Lactuca sativa | - |
- |
- |
Mus musculus | - |
- |
- |
Neurospora crassa | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas fluorescens | - |
- |
- |
Pseudomonas vulgaris | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Serratia marcescens | - |
- |
- |
Triticum aestivum | - |
wheat | - |
Vigna radiata var. radiata | - |
mung bean | - |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Salmonella enterica subsp. enterica serovar Typhimurium | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Vigna radiata var. radiata | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Bacillus subtilis | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Mus musculus | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Escherichia coli | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Rattus norvegicus | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Saccharomyces cerevisiae | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Triticum aestivum | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Oryctolagus cuniculus | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Neurospora crassa | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Pseudomonas fluorescens | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Klebsiella aerogenes | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Pseudomonas aeruginosa | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Halobacterium salinarum | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Serratia marcescens | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Enterococcus faecalis | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Azotobacter vinelandii | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Lactuca sativa | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Citrobacter freundii | |
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Pseudomonas vulgaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Oryctolagus cuniculus | - |
germ | - |
Vigna radiata var. radiata | - |
germ | - |
Triticum aestivum | - |
seedling | - |
Vigna radiata var. radiata | - |
seedling | - |
Lactuca sativa | - |
spleen | - |
Mus musculus | - |
spleen | - |
Rattus norvegicus | - |
spleen | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbamoyl phosphate + L-aspartate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Vigna radiata var. radiata | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Bacillus subtilis | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Mus musculus | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Escherichia coli | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Rattus norvegicus | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Saccharomyces cerevisiae | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Triticum aestivum | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Oryctolagus cuniculus | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Neurospora crassa | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Pseudomonas fluorescens | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Klebsiella aerogenes | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Pseudomonas aeruginosa | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Halobacterium salinarum | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Serratia marcescens | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Enterococcus faecalis | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Azotobacter vinelandii | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Lactuca sativa | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Citrobacter freundii | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoyl phosphate + L-aspartate | - |
Pseudomonas vulgaris | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Vigna radiata var. radiata | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Bacillus subtilis | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Mus musculus | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Rattus norvegicus | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Saccharomyces cerevisiae | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Triticum aestivum | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Oryctolagus cuniculus | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Neurospora crassa | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Pseudomonas fluorescens | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Klebsiella aerogenes | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Pseudomonas aeruginosa | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Halobacterium salinarum | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Serratia marcescens | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Enterococcus faecalis | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Azotobacter vinelandii | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Lactuca sativa | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Citrobacter freundii | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | - |
Pseudomonas vulgaris | phosphate + N-carbamoyl-L-aspartate | - |
? | |
carbamoylphosphate + L-aspartate | catalyzes the formation of carbamoyl-L-aspartate, the first compound unique to the biosynthetic pathway for pyrimidine nucleotides | Escherichia coli | phosphate + N-carbamoyl-L-aspartate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | - |
Serratia marcescens |
More | 2 distinct kinds of separable subunits, a catalytically active C subunit of 33000 Da and a regulatory R subunit of 17000 Da, native structure: (C3)2(R2)3 i.e. a dimer of C subunits and a trimer of R subunits | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Bacillus subtilis |
8.5 | - |
- |
Pseudomonas fluorescens |
8.5 | - |
maxima at pH 8.5 and pH 10.2 | Escherichia coli |
10.2 | - |
- |
Vigna radiata var. radiata |
10.2 | - |
maxima at pH 8.5 and pH 10.2 | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | activates | Escherichia coli | |
dATP | stimulates | Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000027 | - |
N-(phosphonacetyl)-L-aspartate | - |
Escherichia coli | |
0.037 | - |
CTP | - |
Escherichia coli | |
0.09 | - |
diphosphate | - |
Escherichia coli | |
0.66 | - |
phosphonoacetamide | - |
Escherichia coli | |
1.54 | - |
N-methyl phosphonoacetamide | - |
Escherichia coli |