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Literature summary for 2.1.3.15 extracted from

  • Evans, A.; Ribble, W.; Schexnaydre, E.; Waldrop, G.L.
    Acetyl-CoA carboxylase from Escherichia coli exhibits a pronounced hysteresis when inhibited by palmitoyl-acyl carrier protein (2017), Arch. Biochem. Biophys., 636, 100-109 .
    View publication on PubMed
Search for more literature for 2.1.3.15

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA product inhibition Escherichia coli
palmitoyl-acyl carrier protein allosteric, time-dependent, competitive inhibition Escherichia coli
pantothenic acid potent inhibitor Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA Escherichia coli
-
 [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
 r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
-
 Escherichia coli [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
 r

Synonyms

Synonyms Comment Organism
ACC
-
 Escherichia coli
acetyl-CoA carboxylase
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0439
-
 pantothenic acid at pH 7.8 and 25°C Escherichia coli
0.088
-
 palmitoyl-acyl carrier protein at pH 7.8 and 25°C Escherichia coli