Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Co2+ | inhibits AP3 production at 0.5-2 mM | Actinosynnema pretiosum | |
Cu2+ | inhibits AP3 production slightly at 0.5 mM | Actinosynnema pretiosum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | MCT activity is inhibited at 48 h by Mg2+, and then enhanced to a higher level compared with the control, increase of AP3 production is optimally at 2 mM | Actinosynnema pretiosum | |
Mn2+ | activates AP3 production slightly at 5 mM | Actinosynnema pretiosum | |
additional information | cell growth in presence of different metal ions, overview | Actinosynnema pretiosum | |
Zn2+ | activates AP3 production slightly at 2 mM | Actinosynnema pretiosum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Actinosynnema pretiosum | - |
- |
- |
Actinosynnema pretiosum ATCC 31565 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
MCT | - |
Actinosynnema pretiosum |
methylmalonyl-CoA carboxyltransferase | - |
Actinosynnema pretiosum |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in production of anticancer ansamitocin P-3, AP-3 by submerged cultures of Actinosynnema pretiosum in medium containing agro-industrial residues. The production is increased by addition of metal ions, especially Mg2+ | Actinosynnema pretiosum |