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Literature summary for 2.1.2.5 extracted from

  • Hennig, D.; Scales, S.J.; Moreau, A.; Murley, L.L.; De Mey, J.; Kreis, T.E.
    A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules (1998), J. Biol. Chem., 273, 19602-19611.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloning and sequencing of the cDNA coding for p60, the chicken homologue of bifunctional formiminotransferase cyclodeaminase, a protein of 541 amino acids Gallus gallus
expressed in HeLa cells Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Gallus gallus 5829
-
Golgi membrane localized on Golgi membranes as well as on some potentially Golgi complex-derived vesicular structures Gallus gallus 139
-
Golgi vesicle localized on Golgi membranes as well as on some potentially Golgi complex-derived vesicular structures Gallus gallus
-
-
microtubule microtubule-binding protein Gallus gallus 5874
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59100
-
x * 59100, calculated from the amino acid sequence Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-formiminoglutamate + tetrahydrofolate Gallus gallus in addition to its enzymatic activity enzyme may have a second physiological function in mediating interaction of Golgi-derived membranes with microtubules 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate Gallus gallus histidine degradation 5-formiminotetrahydrofolate + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus Q9YH58 chicken, several isoforms of p60, bifunctional formiminotransferase cyclodeaminase
-
Meleagris gallopavo
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information p60, bifunctional formiminotransferase cyclodeaminase, is post-translationally modified Gallus gallus

Purification (Commentary)

Purification (Comment) Organism
purification from liver Meleagris gallopavo
purification from liver Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell DU249 chicken hepatoma cells, contain p60 but no measurable formiminotransferase activity, may be due to the low expression of p60 Gallus gallus
-
liver
-
Meleagris gallopavo
-
liver
-
Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
10.5
-
-
Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information p60: bifunctional formiminotransferase cyclodeaminase, can mediate interaction between trans-Golgi network derived vesicles and microtubule in vitro, p60 may bind to the polyglutamate on microtubules, globular hydrophilic protein Meleagris gallopavo ?
-
?
additional information p60: bifunctional formiminotransferase cyclodeaminase, can mediate interaction between trans-Golgi network derived vesicles and microtubule in vitro, p60 may bind to the polyglutamate on microtubules, globular hydrophilic protein Gallus gallus ?
-
?
N-formiminoglutamate + tetrahydrofolate in addition to its enzymatic activity enzyme may have a second physiological function in mediating interaction of Golgi-derived membranes with microtubules Gallus gallus 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate histidine degradation Gallus gallus 5-formiminotetrahydrofolate + L-glutamate
-
?
tetrahydrofolate + N-formimino-L-glutamate
-
Meleagris gallopavo 5-formiminotetrahydrofolate + L-glutamate
-
?
tetrahydrofolate + N-formimino-L-glutamate
-
Gallus gallus 5-formiminotetrahydrofolate + L-glutamate
-
?

Subunits

Subunits Comment Organism
? x * 59100, calculated from the amino acid sequence Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
pI: 6.13 Gallus gallus