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Literature summary for 2.1.2.3 extracted from

  • Riedinger, C.; Mendler, M.; Schlotterer, A.; Fleming, T.; Okun, J.; Hammes, H.P.; Herzig, S.; Nawroth, P.P.
    High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans (2018), J. Biol. Chem., 293, 4845-4859 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.2.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Caenorhabditis elegans
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 tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Caenorhabditis elegans Q95QQ4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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 Caenorhabditis elegans tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

Synonyms

Synonyms Comment Organism
5-aminoimidazole-4-carboxamideribonucleotide formyltransferase
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 Caenorhabditis elegans
AICAR-transformylase
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 Caenorhabditis elegans
AICAR-transformylase/IMP cyclohydrolase
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 Caenorhabditis elegans
AICARFT
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 Caenorhabditis elegans
ATIC bifunational enzyme with AICAR-transformylase and IMP cyclohydrolase activities Caenorhabditis elegans
atic-1
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 Caenorhabditis elegans
C55F2.1
-
 Caenorhabditis elegans

Expression

Organism Comment Expression
Caenorhabditis elegans high glucose up-regulates the expression and activity of the enzyme and increases the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of the enzyme (atic-1) decreases the lifespan and head motility and increases neuronal damage under both standard and high glucose conditions up
Caenorhabditis elegans there is approximately 2.7fold increased enzyme expression at 5 days of high glucose (13 mM) compared with standard conditions (5 mM) up

General Information

General Information Comment Organism
metabolism the enzyme AICAR-transformylase/IMP cyclohydrolase (ATIC) catalyzes the last two steps of purine de novo synthesis. High glucose up-regulates the expression and activity of the enzyme and increases the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of the enzyme (atic-1) decreases the lifespan and head motility and increases neuronal damage under both standard and high glucose conditions. Inhibition of atic-1 expression, by RNAi, under high glucose is associated with increased lifespan and head motility and reduced neuronal damage, reactive oxygen species, and methylglyoxal-derived advanced glycation end product accumulation. The enzyme (atic-1) is involved in glucotoxic effects under high glucose conditions, either by blocked atic-1 expression or via induction of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and AMP-activated kinase (AMPK) induction Caenorhabditis elegans
physiological function enzyme overexpression decreases the median lifespan from 23.6 to 20.6 days compared with control nematodes under standard conditions Caenorhabditis elegans