Literature summary for 2.1.2.3 extracted from

Markandeyan, D.; Kannaiyan, S.; Suresh, S.; Nimmakayala, R.; Ilamurugan, R.; Santhalingam, K.; Paul, B.
Virtual screening of phytochemicals for methotrexate like dihydrofolate reductase and aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase inhibitory property using Molegro virtual docker (2016), Int. J. Pharm. Pharm. Sci., 8, 83-87 .

No PubMed abstract available

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Inhibitors

Inhibitors	Comment	Organism	Structure
calotropin	-	Homo sapiens
dicrocin	-	Homo sapiens
mauritine A	-	Homo sapiens
melianone	-	Homo sapiens
methotrexate	-	Homo sapiens
uscharidin	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide	Homo sapiens	-	tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P31939	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide	-	Homo sapiens	tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide	-	?

Synonyms

Synonyms	Comment	Organism
5-aminoimidazole-4-carboxamide ribonucleotide	-	Homo sapiens
AICAR transformylase	-	Homo sapiens
ATIC	bifunctional enzyme with 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities	Homo sapiens

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Release 2023.1 (January 2023)