Literature summary for 2.1.2.3 extracted from

Reyes, V.M.; Greasley, S.E.; Stura, E.A.; Beardsley, G.P.; Wilson, I.A.
Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli (2000), Acta Crystallogr. Sect. D, 56, 1051-1054.

No PubMed abstract available

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Application

Application	Comment	Organism
medicine	attractive anticancer target	Gallus sp.

Crystallization (Commentary)

Crystallization (Comment)	Organism
ATIC complex crystallized in monoclinic space group P2(1), a = 56.48 A, b = 107.88 A, c = 103.86 A and beta = 91.2°	Gallus sp.
crystallized in a binary complex with methotrexate, single crystal at 96 K to 2.3 A resolution, monoclinic crystals, space group P2(1), with unit-cell dimensions a = 65.17, B = 105.93, c= 103.47 A, beta = 108.27 degrees	Gallus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide	Gallus sp.	penultimate and final steps in the de novo purine biosynthesis pathway	tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide	-	r

Organism

Organism	UniProt	Comment	Textmining
Gallus sp.	-	avian	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant avian ATIC, purified from E. coli expression system	Gallus sp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide	penultimate and final steps in the de novo purine biosynthesis pathway	Gallus sp.	tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide	-	r
additional information	in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene	Gallus sp.	?	-	?
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide	-	Gallus sp.	tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide	-	r

Synonyms

Synonyms	Comment	Organism
5-aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase)-inosine monophosphate cyclohydrolase	-	Gallus sp.
ATIC	-	Gallus sp.
IMPCH	-	Gallus sp.

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Release 2023.1 (January 2023)