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Literature summary for 2.1.2.2 extracted from
- LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes (1997), Cancer Res., 57, 1116-1123.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LY231514 | antitumor activity may result from simultaneous and multiple inhibition of several key folate-requiring enzymes via its polyglutamated metabolites | Homo sapiens |  |
| LY231514 monoglutamate | - |
Homo sapiens | |
| LY231514 pentaglutamate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GARFT | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000065 | - |
LY231514 pentaglutamate | - |
Homo sapiens | |
| 0.0093 | - |
LY231514 monoglutamate | - |
Homo sapiens | |
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