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Literature summary for 2.1.2.10 extracted from

  • Lee, H.H.; Kim do, J.; Ahn, H.J.; Ha, J.Y.; Suh, S.W.
    Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia (2004), J. Biol. Chem., 279, 50514-50523.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
apoform, tetrahydrofolate complex, folinic acid complex and lipoic acid complex of enzyme, homology model of human enzyme Thermotoga maritima

Organism

Organism UniProt Comment Textmining
Thermotoga maritima
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Reaction

Reaction Comment Organism Reaction ID
[protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3 tetrahydrofolate is bound near the center of the tripartite enzyme, lipoic acid is bound adjacent to the tetrahydrofolate binding pocket Thermotoga maritima