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Literature summary for 2.1.2.1 extracted from

  • Li, X.; Yang, J.; Pu, Q.; Peng, X.; Xu, L.; Liu, S.
    Serine hydroxymethyltransferase controls blood-meal digestion in the midgut of Aedes aegypti mosquitoes (2019), Parasit. Vectors, 12, 460 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Aedes aegypti

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + glycine + H2O Aedes aegypti
-
tetrahydrofolate + L-serine
-
r
5,10-methylenetetrahydrofolate + glycine + H2O Aedes aegypti NIH Rockefeller
-
tetrahydrofolate + L-serine
-
r
tetrahydrofolate + L-serine Aedes aegypti
-
5,10-methylenetetrahydrofolate + glycine + H2O
-
r
tetrahydrofolate + L-serine Aedes aegypti NIH Rockefeller
-
5,10-methylenetetrahydrofolate + glycine + H2O
-
r

Organism

Organism UniProt Comment Textmining
Aedes aegypti
-
-
-
Aedes aegypti NIH Rockefeller
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni ion affinity column chromatography Aedes aegypti

Source Tissue

Source Tissue Comment Organism Textmining
midgut
-
Aedes aegypti
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + glycine + H2O
-
Aedes aegypti tetrahydrofolate + L-serine
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
-
Aedes aegypti NIH Rockefeller tetrahydrofolate + L-serine
-
r
tetrahydrofolate + L-serine
-
Aedes aegypti 5,10-methylenetetrahydrofolate + glycine + H2O
-
r
tetrahydrofolate + L-serine
-
Aedes aegypti NIH Rockefeller 5,10-methylenetetrahydrofolate + glycine + H2O
-
r

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Aedes aegypti

Synonyms

Synonyms Comment Organism
serine hydroxymethyltransferase
-
Aedes aegypti
SHMT
-
Aedes aegypti

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Aedes aegypti

General Information

General Information Comment Organism
malfunction digestion of blood is inhibited in enzyme RNAi-silenced female Aedes aegypti mosquitoes. Enzyme-depleted female mosquitoes lose their flight ability and die within 48 h of a blood meal Aedes aegypti