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Literature summary for 2.1.2.1 extracted from

  • Fox, J.T.; Shin, W.K.; Caudill, M.A.; Stover, P.J.
    A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair (2009), J. Biol. Chem., 284, 31097-31108.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.2.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus SHMT1 localizes to the nucleus in response to UV treatment Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
Hs 925.T cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + tetrahydrofolate
-
 Homo sapiens glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Synonyms

Synonyms Comment Organism
serine hydroxymethyltransferase 1
-
 Homo sapiens
SHMT1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens a non-lethal dose of UV-C radiation (10 mJ/cm2 UV (254 nm)) increases SHMT1 internal ribosome entry site activity and protein levels up

General Information

General Information Comment Organism
physiological function the UV-induced increase in SHMT1 translation is accompanied by an increase in the small ubiquitin-like modifier-dependent nuclear localization of the de novo thymidylate biosynthesis pathway and a decrease in DNA strand breaks, suggesting that SHMT1 plays a role in DNA repair Homo sapiens