Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.2.1 extracted from

  • Fox, J.T.; Stover, P.J.
    Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1 (2009), J. Biol. Chem., 284, 31085-31096.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + tetrahydrofolate Homo sapiens
-
glycine + 5,10-methylenetetrahydrofolate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + tetrahydrofolate
-
Homo sapiens glycine + 5,10-methylenetetrahydrofolate + H2O
-
?

Synonyms

Synonyms Comment Organism
serine hydroxymethyltransferase 1
-
Homo sapiens
SHMT1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens heterogeneous nuclear ribonucleoprotein H2 stimulates SHMT1 internal ribosome entry site activity by binding to the 5‘-untranslated region of the transcript and interacting with CUG-binding protein 1, CUG-binding protein 1 stimulates the internal ribosome entry site-mediated translation of SHMT1 up

General Information

General Information Comment Organism
metabolism SHMT1 is a rate-limiting enzyme in de novo thymidylate biosynthesis Homo sapiens