Literature summary for 2.1.2.1 extracted from

Perry, C.; Sastry, R.; Nasrallah, I.M.; Stover, P.J.
Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc: implications for inhibition of DNA replication (2005), J. Biol. Chem., 280, 396-400.

Search for more literature for 2.1.2.1

Application

Application	Comment	Organism
analysis	SHMT1 is a zinc-inducible gene, provides first mechanism for the regulation of folate-mediated one-carbon metabolism by zinc	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
into the pGL3 vector and transfected into MCF-7 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	mutation of the consensus metal regulatory element sequence decreases the promoter activity of the -219 to -1 fragment by 60% in the absence of L-mimosine and attenuates L-mimosine inhibition by nearly 40%, mutation of the NF1 consensus sequence in the SHMT1 promoter -219 to -1 partially attenuates L-mimosine inhibition by ca. 20% without influencing SHMT1 promoter activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
L-mimosine	inhibits SHMT1 transcription by chelating zinc, eliminates the metal regulatory element- and Sp1-binding activity in nuclear extracts from MCF-7 cells, but not in nuclear extracts from the mimosine-resistant cell line, MCF-7/2a	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zinc	within a mimosine-responsive transcriptional element localized within the first 50 base pairs of the human SHMT1 promoter, 50-base-pair sequence contains a consensus zinc-sensing metal regulatory element at position -44 to -38	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-
MCF-7/2a cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
serine hydroxymethyltransferase	-	Homo sapiens
SHMT1	-	Homo sapiens

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Release 2023.1 (January 2023)