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Literature summary for 2.1.2.1 extracted from

  • Stolz, M.; Peters-Wendisch, P.; Etterich, H.; Gerharz, T.; Faurie, R.; Sahm, H.; Fersterra, H.; Eggeling, L.
    Reduced folate supply as a key to enhanced L-serine production by Corynebacterium glutamicum (2007), Appl. Environ. Microbiol., 73, 750-755.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
5,6,7,8-tetrahydrofolate control of SHMT activity by the availability of 5,6,7,8-tetrahydrofolate Corynebacterium glutamicum
pyridoxal 5'-phosphate
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Corynebacterium glutamicum

Application

Application Comment Organism
pharmacology L-serine is required for pharmaceutical purposes, availability of a sugar-based microbial process for its production is desirable, however, SHMT prevents overproduction of L-serine, control of the essential SHMT activity by a novel physiological approach Corynebacterium glutamicum

Protein Variants

Protein Variants Comment Organism
additional information SHMT activity controlled by Ptac, greatly reduced SHMT activity if no isopropyl-thio-beta-D-galactopyranoside is present, is explicitly prone to chromosomal mutations and rearrangements, thus making the strain unsuitable for large-scale fermentations Corynebacterium glutamicum

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum
-
strain ATCC 13032
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + tetrahydrofolate
-
Corynebacterium glutamicum glycine + 5,10-methylenetetrahydrofolate + H2O
-
?

Synonyms

Synonyms Comment Organism
serine hydroxymethyltransferase
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Corynebacterium glutamicum
SHMT
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Corynebacterium glutamicum