Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5,6,7,8-tetrahydrofolate | control of SHMT activity by the availability of 5,6,7,8-tetrahydrofolate | Corynebacterium glutamicum | |
pyridoxal 5'-phosphate | - |
Corynebacterium glutamicum |
Application | Comment | Organism |
---|---|---|
pharmacology | L-serine is required for pharmaceutical purposes, availability of a sugar-based microbial process for its production is desirable, however, SHMT prevents overproduction of L-serine, control of the essential SHMT activity by a novel physiological approach | Corynebacterium glutamicum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | SHMT activity controlled by Ptac, greatly reduced SHMT activity if no isopropyl-thio-beta-D-galactopyranoside is present, is explicitly prone to chromosomal mutations and rearrangements, thus making the strain unsuitable for large-scale fermentations | Corynebacterium glutamicum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corynebacterium glutamicum | - |
strain ATCC 13032 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + tetrahydrofolate | - |
Corynebacterium glutamicum | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
serine hydroxymethyltransferase | - |
Corynebacterium glutamicum |
SHMT | - |
Corynebacterium glutamicum |