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Literature summary for 2.1.2.1 extracted from

  • Goyer, A.; Collakova, E.; Diaz de la Garza, R.; Quinlivan, E.P.; Williamson, J.; Gregory, J.F., 3rd; Shachar-Hill, Y.; Hanson, A.D.
    5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves (2005), J. Biol. Chem., 280, 26137-26142.
    View publication on PubMed
Search for more literature for 2.1.2.1

Protein Variants

Protein Variants Comment Organism
additional information 5-CHO-THF cycloligase mutant, doubled leaf 5-formyltetrahydrofolate level, little impact on SHMT activity, but glycine content of mutant leaves is 19fold higher than the wild-type, also a small accumulation of serine in the mutant relative to the wild-type Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
5-formyltetrahydrofolate can inhibit SHMT in vivo and thereby influence glycine pool size, can accumulate glycine in both wild-type and 5-CHO-THF cycloligase mutant Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Arabidopsis thaliana 5739
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + tetrahydrofolate
-
 Arabidopsis thaliana glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Synonyms

Synonyms Comment Organism
serine hydroxymethyltransferase
-
 Arabidopsis thaliana
SHMT
-
 Arabidopsis thaliana