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Literature summary for 2.1.2.1 extracted from

  • Fratte, S.D.; White, R.H.; Maras, B.; Bossa, F.; Schirch, V.
    Purification and properties of serine hydroxymethyltransferase from Sulfolobus solfataricus (1997), J. Bacteriol., 179, 7456-7461.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.2.1

Inhibitors

Inhibitors Comment Organism Structure
L-cysteine
-
 Saccharolobus solfataricus
NaCNBH3
-
 Saccharolobus solfataricus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
 2 * 53000, SDS-PAGE Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + tetrahydrofolate Saccharolobus solfataricus key enzyme of serine pathway for assimilation of C1-compounds glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
L-serine + tetrahydrofolate Saccharolobus solfataricus P2 key enzyme of serine pathway for assimilation of C1-compounds glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q9UWT5
-
-
Saccharolobus solfataricus P2 Q9UWT5
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Saccharolobus solfataricus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Saccharolobus solfataricus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + modified folate not: tetrahydrofolate, synthetic modified folate derivate Saccharolobus solfataricus glycine + modified methylenefolate
-
 ?
L-serine + modified folate not: tetrahydrofolate, synthetic modified folate derivate Saccharolobus solfataricus P2 glycine + modified methylenefolate
-
 ?
L-serine + tetrahydrofolate key enzyme of serine pathway for assimilation of C1-compounds Saccharolobus solfataricus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
L-serine + tetrahydrofolate key enzyme of serine pathway for assimilation of C1-compounds Saccharolobus solfataricus P2 glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 53000, SDS-PAGE Saccharolobus solfataricus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Saccharolobus solfataricus