Any feedback?
Literature summary for 2.1.2.1 extracted from
- Serine hydroxymethyltransferase (1982), Adv. Enzymol. Relat. Areas Mol. Biol., 53, 83-112.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-alanine | - |
Bos taurus |  |
| D-alanine | - |
Cricetulus griseus | |
| D-alanine | - |
Oryctolagus cuniculus | |
| D-alanine | - |
Ovis aries | |
| D-beta-fluoroalanine | - |
Bos taurus | |
| D-beta-fluoroalanine | - |
Cricetulus griseus | |
| D-beta-fluoroalanine | - |
Oryctolagus cuniculus | |
| D-beta-fluoroalanine | - |
Ovis aries | |
| D-cycloserine | - |
Bos taurus | |
| D-cycloserine | - |
Cricetulus griseus | |
| D-cycloserine | - |
Oryctolagus cuniculus | |
| D-cycloserine | - |
Ovis aries | |
| L-methionine | - |
Saccharomyces cerevisiae | |
| methyl methanethiosulfonate | - |
Bos taurus | |
| methyl methanethiosulfonate | - |
Cricetulus griseus | |
| methyl methanethiosulfonate | - |
Oryctolagus cuniculus | |
| methyl methanethiosulfonate | - |
Ovis aries | |
| S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae | |
| tetrahydrofolate derivatives | - |
Bos taurus | |
| tetrahydrofolate derivatives | - |
Cricetulus griseus | |
| tetrahydrofolate derivatives | - |
Oryctolagus cuniculus | |
| tetrahydrofolate derivatives | - |
Ovis aries |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Saccharomyces cerevisiae | |
| additional information | - |
additional information | pH-dependence of kinetic parameters | Cricetulus griseus | |
| additional information | - |
additional information | pH-dependence of kinetic parameters | Bos taurus | |
| additional information | - |
additional information | pH-dependence of kinetic parameters | Oryctolagus cuniculus | |
| additional information | - |
additional information | pH-dependence of kinetic parameters | Ovis aries |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 5737 | - |
| cytoplasm | - |
Cricetulus griseus | 5737 | - |
| cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
| cytoplasm | - |
Bos taurus | 5737 | - |
| cytoplasm | - |
Oryctolagus cuniculus | 5737 | - |
| cytoplasm | - |
Neurospora crassa | 5737 | - |
| cytoplasm | - |
Ovis aries | 5737 | - |
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
| mitochondrion | matrix | Cricetulus griseus | 5739 | - |
| mitochondrion | matrix | Bos taurus | 5739 | - |
| mitochondrion | matrix | Oryctolagus cuniculus | 5739 | - |
| mitochondrion | matrix | Ovis aries | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine + tetrahydrofolate | Saccharomyces cerevisiae | - |
glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | Salmonella enterica subsp. enterica serovar Typhimurium | may play important role in central nervous system | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | Cricetulus griseus | may play important role in central nervous system | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | Bos taurus | may play important role in central nervous system | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | Oryctolagus cuniculus | may play important role in central nervous system | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | Neurospora crassa | may play important role in central nervous system | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | Ovis aries | may play important role in central nervous system | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cricetulus griseus | - |
- |
- |
| Neurospora crassa | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Ovis aries | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Cricetulus griseus | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Bos taurus | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Oryctolagus cuniculus | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Neurospora crassa | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Ovis aries | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | stereochemistry | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | stereochemistry | Cricetulus griseus | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | stereochemistry | Bos taurus | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | stereochemistry | Oryctolagus cuniculus | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | stereochemistry | Neurospora crassa | |
| 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | stereochemistry | Ovis aries |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovary | - |
Cricetulus griseus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| frozen, several months at pH 7.3 | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-methylserine + tetrahydrofolate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
| alpha-methylserine + tetrahydrofolate | - |
Cricetulus griseus | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
| alpha-methylserine + tetrahydrofolate | - |
Saccharomyces cerevisiae | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
| alpha-methylserine + tetrahydrofolate | - |
Bos taurus | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
| alpha-methylserine + tetrahydrofolate | - |
Oryctolagus cuniculus | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
| alpha-methylserine + tetrahydrofolate | - |
Neurospora crassa | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
| alpha-methylserine + tetrahydrofolate | - |
Ovis aries | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
| L-serine + tetrahydrofolate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | - |
Cricetulus griseus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | - |
Saccharomyces cerevisiae | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | - |
Bos taurus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | - |
Oryctolagus cuniculus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
r | |
| L-serine + tetrahydrofolate | - |
Neurospora crassa | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | - |
Ovis aries | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
r | |
| L-serine + tetrahydrofolate | may play important role in central nervous system | Salmonella enterica subsp. enterica serovar Typhimurium | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | may play important role in central nervous system | Cricetulus griseus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | may play important role in central nervous system | Bos taurus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | may play important role in central nervous system | Oryctolagus cuniculus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | may play important role in central nervous system | Neurospora crassa | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| L-serine + tetrahydrofolate | may play important role in central nervous system | Ovis aries | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
| additional information | - |
Saccharomyces cerevisiae | ? | - |
? | |
| additional information | no: L-threonine | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| additional information | no: L-threonine | Cricetulus griseus | ? | - |
? | |
| additional information | no: L-threonine | Bos taurus | ? | - |
? | |
| additional information | no: L-threonine | Oryctolagus cuniculus | ? | - |
? | |
| additional information | no: L-threonine | Neurospora crassa | ? | - |
? | |
| additional information | no: L-threonine | Ovis aries | ? | - |
? | |
| additional information | no: D-serine | Cricetulus griseus | ? | - |
? | |
| additional information | no: D-serine | Bos taurus | ? | - |
? | |
| additional information | no: D-serine | Oryctolagus cuniculus | ? | - |
? | |
| additional information | no: D-serine | Ovis aries | ? | - |
? | |
| additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Cricetulus griseus | ? | - |
? | |
| additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Bos taurus | ? | - |
? | |
| additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Oryctolagus cuniculus | ? | - |
? | |
| additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Neurospora crassa | ? | - |
? | |
| additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Ovis aries | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | - |
Cricetulus griseus |
| homotetramer | - |
Saccharomyces cerevisiae |
| homotetramer | - |
Bos taurus |
| homotetramer | - |
Oryctolagus cuniculus |
| homotetramer | - |
Ovis aries |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
several h, pH 5.8-8.5, cytosol | Oryctolagus cuniculus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5.8 | 8.5 | stable, rabbit cytosol | Oryctolagus cuniculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Saccharomyces cerevisiae | |
| pyridoxal 5'-phosphate | requirement, 4 mol per mol enzyme | Cricetulus griseus | |
| pyridoxal 5'-phosphate | requirement, 4 mol per mol enzyme | Bos taurus | |
| pyridoxal 5'-phosphate | requirement, 4 mol per mol enzyme | Oryctolagus cuniculus | |
| pyridoxal 5'-phosphate | requirement, 4 mol per mol enzyme | Ovis aries | |
| pyridoxal 5'-phosphate | mechanism, active-site structure | Cricetulus griseus | |
| pyridoxal 5'-phosphate | mechanism, active-site structure | Bos taurus | |
| pyridoxal 5'-phosphate | mechanism, active-site structure | Oryctolagus cuniculus | |
| pyridoxal 5'-phosphate | mechanism, active-site structure | Ovis aries | |
| tetrahydrofolate | requirement with L-serine or L-2-methylserine as substrate | Cricetulus griseus | |
| tetrahydrofolate | requirement with L-serine or L-2-methylserine as substrate | Saccharomyces cerevisiae | |
| tetrahydrofolate | requirement with L-serine or L-2-methylserine as substrate | Bos taurus | |
| tetrahydrofolate | requirement with L-serine or L-2-methylserine as substrate | Oryctolagus cuniculus | |
| tetrahydrofolate | requirement with L-serine or L-2-methylserine as substrate | Ovis aries | |
| tetrahydrofolate | mechanism | Cricetulus griseus | |
| tetrahydrofolate | mechanism | Bos taurus | |
| tetrahydrofolate | mechanism | Oryctolagus cuniculus | |
| tetrahydrofolate | mechanism | Ovis aries | |
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