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Literature summary for 2.1.2.1 extracted from
- Serine transhydroxymethylase. Identification as the threonine and allothreonine aldolases (1968), J. Biol. Chem., 243, 5651-5655.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-aminoisobutyrate | - |
Oryctolagus cuniculus |  |
| allothreonine | - |
Oryctolagus cuniculus | |
| aminoisobutyrate | - |
Oryctolagus cuniculus | |
| D-alanine | - |
Oryctolagus cuniculus | |
| DL-allothreonine | - |
Oryctolagus cuniculus | |
| glycine | - |
Oryctolagus cuniculus | |
| L-serine | - |
Oryctolagus cuniculus | |
| L-threonine | - |
Oryctolagus cuniculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.15 | 0.9 | L-serine | - |
Oryctolagus cuniculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.43 | - |
- |
Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine + tetrahydrofolate | - |
Oryctolagus cuniculus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | requirement, 4 mol per mol enzyme | Oryctolagus cuniculus | |
| tetrahydrofolate | requirement with L-serine or L-2-methylserine as substrate | Oryctolagus cuniculus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | comparison of Ki for allothreonine and threonine | Oryctolagus cuniculus | |
| 0.7 | 0.9 | L-serine | - |
Oryctolagus cuniculus | |
| 2.7 | - |
DL-allothreonine | - |
Oryctolagus cuniculus | |
| 2.7 | 6.8 | glycine | - |
Oryctolagus cuniculus | |
| 13 | 23 | aminoisobutyrate | - |
Oryctolagus cuniculus | |
| 40 | 55 | D-alanine | - |
Oryctolagus cuniculus | |
| 50 | - |
L-threonine | - |
Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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