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Literature summary for 2.1.2.1 extracted from

  • Masuda, T.; Sakamoto, M.; Nishizaki, I.; Hayashi, H.; Yamamoto, M.; Wada, H.
    Affinity purification and characterization of serine hydroxymethyltransferases from rat liver (1987), J. Biochem., 101, 643-652.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
beta-Alanine weak Rattus norvegicus
beta-Aminoalanine
-
Rattus norvegicus
glycine
-
Rattus norvegicus
L-alanine
-
Rattus norvegicus
L-amino acids weak, e.g. L-aspartic acid, ornithine, lysine, methionine, phenylalanine, homoserine, threonine, 4-aminobutyric acid Rattus norvegicus
L-cysteine mitochondrial enzyme Rattus norvegicus
L-serine strong Rattus norvegicus
additional information not: mercaptopropionic acid, mercaptoethanolamine; not: valine, leucine, glutamic acid, 3-hydroxybutyric acid Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.15 0.9 L-serine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-
mitochondrion
-
Rattus norvegicus 5739
-
additional information comparison of cytosolic and mitochondrial forms of enzyme Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
4 * 54000, SDS-PAGE Rattus norvegicus
220000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + tetrahydrofolate Rattus norvegicus major pathway for production of C1-units of 5,10-methylenetetrahydrofolate glycine + 5,10-methylenetetrahydrofolate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
affinity chromatography on L-adsorbent Sepharose Rattus norvegicus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + tetrahydrofolate
-
Rattus norvegicus glycine + 5,10-methylenetetrahydrofolate + H2O
-
r
L-serine + tetrahydrofolate major pathway for production of C1-units of 5,10-methylenetetrahydrofolate Rattus norvegicus glycine + 5,10-methylenetetrahydrofolate + H2O
-
?
additional information no: L-threonine Rattus norvegicus ?
-
?
additional information no: D-serine Rattus norvegicus ?
-
?
additional information no: D-allothreonine Rattus norvegicus ?
-
?
additional information no: D-threonine Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
homotetramer 4 * 54000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
pI, cytosolic enzyme: 4.5, pI, mitochondrial enzyme: 4.8 Rattus norvegicus
6.8 8
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate requirement, 4 mol per mol enzyme Rattus norvegicus
tetrahydrofolate requirement with L-serine or L-2-methylserine as substrate Rattus norvegicus