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Literature summary for 2.1.1.B122 extracted from

  • Fitzsimmons, C.M.; Fujimori, D.G.
    Determinants of tRNA recognition by the radical SAM enzyme RlmN (2016), PLoS ONE, 11, e0167298.
    View publication on PubMed
Search for more literature for 2.1.1.B122

Protein Variants

Protein Variants Comment Organism
C118A loss of tRNA methylation activity Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAArgACG Escherichia coli
-
 S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAArgACG
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAAspGUC Escherichia coli
-
 S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAAspGUC
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAGlnCUG Escherichia coli
-
 S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAGlnCUG
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAGlnUUG Escherichia coli
-
 S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAGlnUUG
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAGluUUC Escherichia coli
-
 S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAGluUUC
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAHisGUG Escherichia coli
-
 S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAHisGUG
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no substrate: adenine 37 in tRNAGlyCCC. Position 38 of tRNAs as a critical determinant of substrate recognition. tRNA methylation requirements are consistent with radical SAM reactivity Escherichia coli ?
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAArgACG
-
 Escherichia coli S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAArgACG
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAAspGUC
-
 Escherichia coli S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAAspGUC
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAGlnCUG
-
 Escherichia coli S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAGlnCUG
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAGlnUUG
-
 Escherichia coli S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAGlnUUG
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAGluUUC
-
 Escherichia coli S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAGluUUC
-
 ?
S-adenosyl-L-methionine + adenine37 in Escherichia coli tRNAHisGUG
-
 Escherichia coli S-adenosyl-L-homocysteine + methyladenine37 in Escherichia coli tRNAHisGUG
-
 ?

Cofactor

Cofactor Comment Organism Structure
4Fe-4S-center required for methylation of tRNA Escherichia coli
NADPH or FldA/Fpr, required for methylation of tRNA Escherichia coli