Literature summary for 2.1.1.96 extracted from

Liu, J.; Yu, L.; Coppin, J.F.; Tokar, E.J.; Diwan, B.A.; Waalkes, M.P.
Fetal arsenic exposure appears to facilitate endocrine disruption by postnatal diethylstilbestrol in neonatal mouse adrenal (2009), Chem. Biol. Interact., 182, 253-258.

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Application

Application	Comment	Organism
medicine	exposure of the mouse to arsenic during a critical period of fetal development may potentially alter adrenal genetic programming, leading to endocrine disruption and potentially enhancing tumor formation together with diethylstilbestrol at other sites much later in life	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Expression

Organism	Comment	Expression
Mus musculus	upon exposure of pregnant mice to sodium arsenate in drinking water and subsequent injection of offspring on postpartum days 1-5 with diethylstilbestrol, transcripts for homocysteine cycling genes betaine-homocysteine methyltransferase and thioether S-methyltransferase and developmental marker genes alpha-fetoprotein, insulin-like growth factor 2 and IGF binding protein-1 are higher than with either treatment alone	up

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Release 2023.1 (January 2023)