Any feedback?
Literature summary for 2.1.1.8 extracted from
- Amitriptyline affects histamine-N-methyltransferase and diamine oxidase activity in rats and guinea pigs (2007), Eur. J. Pharmacol., 574, 201-208.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebrum | - |
Cavia porcellus | - |
| kidney | - |
Cavia porcellus | - |
| kidney | - |
Rattus norvegicus | - |
| large intestine | - |
Cavia porcellus | - |
| lung | RNA expression is amplified after treatment with amitriptyline | Cavia porcellus | - |
| small intestine | - |
Cavia porcellus | - |
| spleen | - |
Rattus norvegicus | - |
| spleen | RNA expression is amplified after treatment with amitriptyline | Cavia porcellus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
enzyme activities are increased in spleen and kidney of amitriptyline treated rats | Rattus norvegicus |
| additional information | - |
enzyme activities are increased in tissues of amitriptyline treated guinea pigs | Cavia porcellus |
| 0.000022 | - |
large intestine, saline treated | Cavia porcellus |
| 0.000028 | - |
large intestine, amitriptyline treated | Cavia porcellus |
| 0.000036 | - |
kidney, saline treated | Cavia porcellus |
| 0.000038 | - |
lung, saline treated | Cavia porcellus |
| 0.000052 | - |
lung, amitriptyline treated | Cavia porcellus |
| 0.000054 | - |
kidney, amitriptyline treated | Cavia porcellus |
| 0.00008 | - |
cerebrum, saline treated | Cavia porcellus |
| 0.000101 | - |
small intestine, saline treated | Cavia porcellus |
| 0.000121 | - |
cerebrum, amitriptyline treated | Cavia porcellus |
| 0.000132 | - |
spleen, saline treated | Cavia porcellus |
| 0.000163 | - |
small intestine, amitriptyline treated | Cavia porcellus |
| 0.000165 | - |
spleen, amitriptyline treated | Cavia porcellus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + histamine | - |
Cavia porcellus | S-adenosyl-L-homocysteine + N-methylhistamine | - |
? |  |
| S-adenosyl-L-methionine + histamine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + N-methylhistamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| histamine N-methyltransferase | - |
Cavia porcellus |
| histamine N-methyltransferase | - |
Rattus norvegicus |
| HNMT | - |
Cavia porcellus |
| HNMT | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Cavia porcellus |
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay | Cavia porcellus |
| 7.5 | - |
assay | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
