Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Salmonella enterica subsp. enterica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | Salmonella enterica subsp. enterica | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Salmonella enterica subsp. enterica E-2375 | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica | - |
serovar typhimurium | - |
Salmonella enterica subsp. enterica E-2375 | - |
serovar typhimurium | - |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography and Superdex S200 gel filtration | Salmonella enterica subsp. enterica |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Salmonella enterica subsp. enterica | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Salmonella enterica subsp. enterica E-2375 | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 23000, SDS-PAGE | Salmonella enterica subsp. enterica |
Synonyms | Comment | Organism |
---|---|---|
PIMT | - |
Salmonella enterica subsp. enterica |
protein isoaspartate methyl transferase | - |
Salmonella enterica subsp. enterica |
General Information | Comment | Organism |
---|---|---|
malfunction | in comparison to wild type, the enzyme deletion strain is found significantly more susceptible to H2O2 (4fold at 2.5 mM) and hypochlorite (90fold at 0.2 mM). Further, the enzyme deletion mutant strain shows hypersusceptibility to interferon-gamma stimulated macrophages | Salmonella enterica subsp. enterica |
physiological function | by repairing iso-Asp to Asp, the enzyme maintains the activities of proteins and thus helps in cellular survival under oxidative stress | Salmonella enterica subsp. enterica |