Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SH-SY5Y cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + delta-sleep-inducing peptide L-isoaspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + delta-sleep-inducing peptide L-aspartate alpha-methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PIMT | - |
Homo sapiens |
protein L-isoaspartyl methyltransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | 5 mM valproic acid enhances protein L-isoaspartyl methyltransferase expression about 2fold through glycogen synthase kinase-3/beta-catenin requires 90 kDa ribosomal S6 kinase. Src, c-Raf, MEK1/2 and extracellular-regulated kinase 1/2 abolish the extracellular-regulated kinase 1/2 phosphorylation stimulated by valproic acid, thus preventing PIMT induction by valproic acid | up |