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Literature summary for 2.1.1.77 extracted from

  • Carter, W.G.; Aswad, D.W.
    Formation, localization, and repair of L-isoaspartyl sites in histones H2A and H2B in nucleosomes from rat liver and chicken erythrocytes (2008), Biochemistry, 47, 10757-10764.
    View publication on PubMed
Search for more literature for 2.1.1.77

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-homocysteine
-
 Gallus gallus
S-adenosyl-L-homocysteine
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleosome
-
 Gallus gallus 786
-
nucleosome
-
 Rattus norvegicus 786
-

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Gallus gallus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + delta-sleep-inducing peptide L-isoaspartate delta-sleep-inducing peptide is WAGGDSGE Gallus gallus S-adenosyl-L-homocysteine + delta-sleep-inducing peptide L-isoaspartate alpha-methyl ester
-
 ?
S-adenosyl-L-methionine + delta-sleep-inducing peptide L-isoaspartate delta-sleep-inducing peptide is WAGGDSGE Rattus norvegicus S-adenosyl-L-homocysteine + delta-sleep-inducing peptide L-isoaspartate alpha-methyl ester
-
 ?
S-adenosyl-L-methionine + histone H2A L-isoaspartate in chicken, iso-L-Asp occurs at the Asp121-Ser122 bond in the flexible C-terminal tail of histone H2A Gallus gallus S-adenosyl-L-homocysteine + histone H2A L-isoaspartate alpha-methyl ester
-
 ?
S-adenosyl-L-methionine + histone H2B L-isoaspartate in chicken, iso-L-Asp occurs at the Asp26-Lys27 bond in the N-terminal tail of histone H2B Gallus gallus S-adenosyl-L-homocysteine + histone H2B L-isoaspartate alpha-methyl ester
-
 ?
S-adenosyl-L-methionine + histone H2B L-isoaspartate in rat, iso-L-Asp occurs at the Asp25-Gly26 bond in the N-terminal tail of histone H2B Rattus norvegicus S-adenosyl-L-homocysteine + histone H2B L-isoaspartate alpha-methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
PIMT
-
 Gallus gallus
PIMT
-
 Rattus norvegicus
protein L-isoaspartyl methyltransferase
-
 Gallus gallus
protein L-isoaspartyl methyltransferase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine competitive inhibitor of PIMT Gallus gallus
S-adenosyl-L-methionine competitive inhibitor of PIMT Rattus norvegicus

General Information

General Information Comment Organism
physiological function PIMT repairs L-iso-Asp sites in aged nucleosomes Gallus gallus
physiological function PIMT repairs L-iso-Asp sites in aged nucleosomes Rattus norvegicus