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Literature summary for 2.1.1.77 extracted from

  • Griffith, S.C.; Sawaya, M.R.; Boutz, D.R.; Thapar, N.; Katz, J.E.; Clarke, S.; Yeates, T.O.
    Crystal Structure of a Protein Repair Methyltransferase from Pyrococcus furiosus with its L-Isoaspartyl Peptide Substrate (2001), J. Mol. Biol., 313, 1103-1116.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
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Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate Pyrococcus furiosus protein repair methyltransferase S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
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?

Organism

Organism UniProt Comment Textmining
Pyrococcus furiosus Q8TZR3
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate
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Pyrococcus furiosus S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
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?
S-adenosyl-L-methionine + protein L-isoaspartate protein repair methyltransferase Pyrococcus furiosus S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
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?

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine active methyl-donating cofactor Pyrococcus furiosus