Literature summary for 2.1.1.74 extracted from

Yamagami, R.; Tomikawa, C.; Shigi, N.; Kazayama, A.; Asai, S.; Takuma, H.; Hirata, A.; Fourmy, D.; Asahara, H.; Watanabe, K.; Yoshizawa, S.; Hori, H.
Folate-/FAD-dependent tRNA methyltransferase from Thermus thermophilus regulates other modifications in tRNA at low temperatures (2016), Genes Cells, 21, 740-754 .

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Organism

Organism	UniProt	Comment	Textmining
Thermus thermophilus	Q5SID2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + uracil54 in tRNA + FADH2	-	Thermus thermophilus	tetrahydrofolate + 5-methyluracil54 in tRNA + FAD	-	?

Synonyms

Synonyms	Comment	Organism
TRMFO	-	Thermus thermophilus

General Information

General Information	Comment	Organism
physiological function	a gene disruption strain does show any growth retardation at 70°C, but shows a slow-growth phenotype at 50°C with an increase in 2'-O-methylguanosine at position 18 and decrease in N1-methyladenosine at position 58 in the tRNA mixture from the mutant strain at 50°C. The protein synthesis activity of the mutant strain is inferior to that of the wild-type strain at 50°C	Thermus thermophilus

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Release 2023.1 (January 2023)