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Literature summary for 2.1.1.74 extracted from
- Biosynthesis of ribothymidine in the transfer RNA of Streptococcus faecalis and Bacillus subtilis. A methylation of RNA involving 5,10-methylenetetrahydrofolate (1976), J. Biol. Chem., 251, 7649-7656.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Enterococcus faecalis | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | Bacillus subtilis | post-transcriptional biosynthesis of ribothymidine in the tRNA | tetrahydrofolate + tRNA TpsiC + FAD | - |
? |  |
| 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | Enterococcus faecalis | post-transcriptional biosynthesis of ribothymidine in the tRNA | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Enterococcus faecalis | - |
- |
- |
| no activity in Micrococcus luteus | - |
strains ATCC 4698 and ATCC12698, formerly Micrococcus lysodeikticus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | - |
Bacillus subtilis | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
| 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | - |
Enterococcus faecalis | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
| 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | post-transcriptional biosynthesis of ribothymidine in the tRNA | Bacillus subtilis | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
| 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | post-transcriptional biosynthesis of ribothymidine in the tRNA | Enterococcus faecalis | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Bacillus subtilis |
| 9 | - |
- |
Enterococcus faecalis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Bacillus subtilis | |
| NADPH | - |
Enterococcus faecalis | |
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Release 2023.1 (January 2023)
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