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Literature summary for 2.1.1.72 extracted from

  • Erova, T.E.; Pillai, L.; Fadl, A.A.; Sha, J.; Wang, S.; Galindo, C.L.; Chopra, A.K.
    DNA adenine methyltransferase influences the virulence of Aeromonas hydrophila (2006), Infect. Immun., 74, 410-424.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.72

Application

Application Comment Organism
medicine essential for the viability of the bacterium, overproduction of Dam in Aeromonas hydrophila SSU reduces the virulence of the pathogen, decreases the motility and T3SS-associated cytotoxicity, but increases both the cytotoxicity and hemolysis associated with Act, mice infected with the Dam-overproducing strain do not die over a tested period of 3 weeks, indicating bacterial attenuation as a result of Dam overproduction Aeromonas hydrophila

Cloned(Commentary)

Cloned (Comment) Organism
in a T7 promoter-based vector system using Escherichia coli ER2566 as a host strain, which can alter the virulence potential Aeromonas hydrophila

Protein Variants

Protein Variants Comment Organism
additional information strain SSU dam chromosomal deletion mutant, is not viable Aeromonas hydrophila

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32662
-
 1 * 34000, SDS-PAGE, 1 * 32662, sequence analysis Aeromonas hydrophila
34000
-
 1 * 34000, SDS-PAGE, 1 * 32662, sequence analysis Aeromonas hydrophila

Organism

Organism UniProt Comment Textmining
Aeromonas hydrophila
-
-
-
Aeromonas hydrophila SSU
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by nickel affinity chromatography Aeromonas hydrophila

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine
-
 Aeromonas hydrophila S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
S-adenosyl-L-methionine + DNA adenine
-
 Aeromonas hydrophila SSU S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Subunits

Subunits Comment Organism
? 1 * 34000, SDS-PAGE, 1 * 32662, sequence analysis Aeromonas hydrophila

Synonyms

Synonyms Comment Organism
Dam
-
 Aeromonas hydrophila
DNA adenine methyltransferase
-
 Aeromonas hydrophila