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Literature summary for 2.1.1.72 extracted from

  • Jeltsch, A.; Christ, F.; Fatemi, M.; Roth, M.
    On the substrate specificity of DNA methyltransferases. Adenine-N6 DNA methyltransferases also modify cytosine residues at position N4 (1999), J. Biol. Chem., 274, 19538-19544.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli
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M.EcoRV, M.EcoRI, Escherichia coli dam methyltransferase and M.FokI enzyme
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Planomicrobium okeanokoites
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine
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Planomicrobium okeanokoites S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
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?
S-adenosyl-L-methionine + DNA adenine methylation of DNA in a sequence specific manner, low substrate specificity with respect to the target base. Cytosine residues can be methylated if they are located in a C:T mismatch base pair at the target position of the enzyme, modification of cytosine residues at position N4 Escherichia coli S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
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?