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Literature summary for 2.1.1.71 extracted from
- Phosphatidylethanolamine methyltransferase and phospholipid methyltransferase activities from Saccharomyces cerevisiae. Enzymological and kinetic properties (1990), Biochim. Biophys. Acta, 1045, 156-163.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| enzyme is encoded by PEM2/OPI3 gene, cloned by complementation | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| HgCl2 | - |
Saccharomyces cerevisiae |  |
| octyl glucoside | - |
Saccharomyces cerevisiae | |
| p-chloromercuriphenylsulfonic acid | - |
Saccharomyces cerevisiae | |
| S-adenosyl-L-homocysteine | - |
Saccharomyces cerevisiae | |
| sodium cholate | - |
Saccharomyces cerevisiae | |
| Triton X-100 | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.054 | - |
phosphatidyl-N-monomethylethanolamine | - |
Saccharomyces cerevisiae | |
| 0.059 | - |
phosphatidyl-N-dimethylethanolamine | - |
Saccharomyces cerevisiae | |
| 0.18 | - |
phosphatidyl-N-dimethylethanolamine | - |
Saccharomyces cerevisiae | |
| 0.38 | - |
phosphatidyl-N-monomethylethanolamine | - |
Saccharomyces cerevisiae | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | leads to a stimulation of activity | Saccharomyces cerevisiae | |
| Mg2+ | leads to a stimulation of activity | Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + phosphatidylcholine | - |
? | |
| S-adenosyl-L-methionine + phosphatidyl-N-monomethylethanolamine | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
- |
Saccharomyces cerevisiae |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
unstable above | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Saccharomyces cerevisiae |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 9.5 | - |
Saccharomyces cerevisiae |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.054 | - |
S-adenosyl-L-homocysteine | phosphatidyl-N-dimethylethanolamine as substrate, competitive inhibition | Saccharomyces cerevisiae | |
| 0.057 | - |
S-adenosyl-L-homocysteine | phosphatidyl-N-monomethylethanolamine as substrate, competitive inhibition | Saccharomyces cerevisiae | |
| 0.12 | - |
S-adenosyl-L-homocysteine | phosphatidyl-N-dimethylethanolamine as substrate, noncompetitive inhibition | Saccharomyces cerevisiae | |
| 0.32 | - |
S-adenosyl-L-homocysteine | phosphatidyl-N-monomethylethanolamine as substrate, noncompetitive inhibition | Saccharomyces cerevisiae | |
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