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Literature summary for 2.1.1.67 extracted from
- Determination of thiopurine S-methyltransferase (TPMT) activity in human erythrocytes by liquid chromatography-tandem mass spectrometry (LC-MS/MS) (2024), Methods Mol. Biol., 2737, 465-472.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P51580 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine-d3 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TPMT | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | thiopurine drugs, azathioprine, mercaptopurine, and thioguanine, are widely used in the treatment of several malignant and nonmalignant diseases. Patients with low-activity variants of thiopurine S-methyltransferase can be affected by pronounced pharmacologic effects when receiving thiopurine medications | Homo sapiens |
| additional information | a method used to determine thiopurine S-methyltransferase activity by measuring 6-MMP by liquid chromatography-tandem mass spectrometry while employing 6-methylmercaptopurine-d3 as an internal standard | Homo sapiens |
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