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Literature summary for 2.1.1.67 extracted from

  • Fukumoto, Y.; Yamada, H.; Matsuhashi, K.; Okada, W.; Tanaka, Y.K.; Suzuki, N.; Ogra, Y.
    Production of a urinary selenium metabolite, trimethylselenonium, by thiopurine S-methyltransferase and indolethylamine N-methyltransferase (2020), Chem. Res. Toxicol., 33, 2467-2474.
    View publication on PubMed
Search for more literature for 2.1.1.67

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P51580
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
heart low mRNA level Homo sapiens
-
kidney the enzyme is preferably expressed in the liver and kidneys Homo sapiens
-
liver the enzyme is preferably expressed in the liver and kidneys Homo sapiens
-
lung low mRNA level Homo sapiens
-
muscle low mRNA level Homo sapiens
-
small intestine intermediate mRNA level Homo sapiens
-
spleen intermediate mRNA level Homo sapiens
-
testis intermediate mRNA level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + monomethylseleninic acid
-
 Homo sapiens S-adenosyl-L-homocysteine + dimethylseleninic acid
-
 ?
S-adenosyl-L-methionine + selenium
-
 Homo sapiens S-adenosyl-L-homocysteine + monomethylseleninic acid
-
 ?

Synonyms

Synonyms Comment Organism
S-methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function both thiopurine S-methyltransferase (TPMT) and indolethylamine N-methyltransferase (INMT) cooperatively contributed to the trimethylselenonium ion production, enabling urinary excretion of Se and maintenance of homeostasis of this essential yet highly toxic trace element. Thus, TPMT and INMT can be recognized as selenium methyltransferases Homo sapiens