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Literature summary for 2.1.1.67 extracted from

  • Tanaka, Y.K.; Takata, A.; Takahashi, K.; Yamagishi, Y.; Fukumoto, Y.; Suzuki, N.; Ogra, Y.
    Thiopurine S-methyltransferase- and indolethylamine N-methyltransferase-mediated formation of methylated tellurium compounds from tellurite (2024), Arch. Toxicol., 99, 237-244.
    View publication on PubMed
Search for more literature for 2.1.1.67

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0035
-
 tellurite pH 6.8, 37°C Homo sapiens
0.0109
-
 methanetellurol pH 6.8, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + methanetellurol Homo sapiens
-
 S-adenosyl-L-homocysteine + dimethyltelluride
-
 ?
S-adenosyl-L-methionine + tellurite Homo sapiens
-
 S-adenosyl-L-homocysteine + dimethyltelluride
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P51580
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + methanetellurol
-
 Homo sapiens S-adenosyl-L-homocysteine + dimethyltelluride
-
 ?
S-adenosyl-L-methionine + tellurite
-
 Homo sapiens S-adenosyl-L-homocysteine + dimethyltelluride
-
 ?

Synonyms

Synonyms Comment Organism
TPMT
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function thiopurine S-methyltransferase and indolethylamine N-methyltransferase are cooperatively responsible for the detoxification of Tellurium oxyanions through methylation to form trimethyltelluronium ions Homo sapiens