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Literature summary for 2.1.1.67 extracted from

  • Roberts, R.L.; Wallace, M.C.; Drake, J.M.; Stamp, L.K.
    Identification of a novel thiopurine S-methyltransferase allele (TPMT 37) (2014), Pharmacogenet. Genomics, 24, 320-323.
    View publication on PubMed
Search for more literature for 2.1.1.67

Protein Variants

Protein Variants Comment Organism
A719G the mutant exhibits reduced activity compared to the wild type enzyme Homo sapiens
C216T the mutant exhibits reduced activity compared to the wild type enzyme Homo sapiens
G238C the mutant exhibits reduced activity compared to the wild type enzyme Homo sapiens
G460A the mutant exhibits reduced activity compared to the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P51580
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + azathioprine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
 ?

Synonyms

Synonyms Comment Organism
TPMT
-
 Homo sapiens