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Literature summary for 2.1.1.67 extracted from

  • Kasirer, Y.; Mevorach, R.; Renbaum, P.; Algur, N.; Soiferman, D.; Beeri, R.; Rachman, Y.; Segel, R.; Turner, D.
    Thiopurine S-methyltransferase (TPMT) activity is better determined by biochemical assay versus genotyping in the Jewish population (2014), Digest. Dis. Sci., 59, 1207-1212.
    View publication on PubMed
Search for more literature for 2.1.1.67

Protein Variants

Protein Variants Comment Organism
A179G/G460A the variant is associated with low enzyme activity Homo sapiens
A719G the variant is associated with low enzyme activity Homo sapiens
G238C the variant is associated with low enzyme activity Homo sapiens
G460A the variant is associated with low enzyme activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P51580
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction intermediate and low enzyme activity may lead to leukopenia following thiopurine treatment Homo sapiens