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Literature summary for 2.1.1.67 extracted from

  • de Boer, N.K.; van Bodegraven, A.A.; de Graaf, P.; van der Hulst, R.W.; Zoetekouw, L.; van Kuilenburg, A.B.
    Paradoxical elevated thiopurine S-methyltransferase activity after pancytopenia during azathioprine therapy: potential influence of red blood cell age (2008), Ther. Drug Monit., 30, 390-393.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine the remarkable change in enzyme activity of TPMT may be explained by differences in the age of red blood cells, as younger erythrocytes have a higher TPMT activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00000716
-
 TMPT reference activity after recovery of the bone marrow suppression Homo sapiens
0.00003033
-
 elevated TPMT activity during the recovery phase of a bone marrow suppression, following the pancytopenic period Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 6-thioinosine-monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine-ribonucleotide consisting of 6-methyl-thioinosine-monophosphate, -diphosphate and triphosphate ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + azathioprine azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine S-methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 TPMT activity assay Homo sapiens