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Literature summary for 2.1.1.67 extracted from

  • Rutherford, K.; Daggett, V.
    Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics (2008), J. Mol. Biol., 379, 803-814.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
A154T polymorphism TPMT*3B Homo sapiens
A154T/Y240C polymorphism TPMT*3A Homo sapiens
A80P polymorphism TPMT*2 Homo sapiens
Y240C polymorphism TPMT*3C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
?
S-adenosyl-L-methionine + 6-thioguanine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
?
S-adenosyl-L-methionine + a thiopurine
-
Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?
S-adenosyl-L-methionine + azathioprine azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
?

Subunits

Subunits Comment Organism
monomer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
thiopurine S-methyltransferase
-
Homo sapiens
TPMT
-
Homo sapiens